Zoo staff will provide around-the-clock bottle feedings and care for the half-pound cub.
"We are delighted with the birth of this cub," zoo general curator Karen Goodrowe Beck said in a news release. "Clouded leopards are very endangered and every one is a precious addition to the population."
The cub is the third born to Chai Li and her mate, Nah Fun, according to zoo officials.
The cub doesn't have a name yet and it's unclear when zoo visitors will be able to see him in person.